Growth of Cell and Biologic Therapies Increasingly Reliant on Advances in Microcarriers Technology

The growing prevalence of cell-based therapy, such as stem-cell therapy (including hematopoietic stem-cell transplantation), as well as the growing need for vaccine production worldwide, are among the key trends driving rapid growth in demand for the use of microcarriers.  According to Reports and Data, the microcarriers market is expected to achieve revenue of nearly US$2.9bn in 2028¹, representing an annual growth rate of 10.5% over a 2020-2028 forecast period.

Specifically designed for the attachment, growth and expansion of cells in a mixing environment (e.g., bioreactors), microcarriers are uniquely suited for both scale-up and large-scale cell production with key attributes being cost efficiency, scalability and ease of use.  Optimizing cell yield, in particular, is critical to the production of large quantities of cells in a bioreactor vessel to ensure cost and time efficiency.  As a result, the utility of microcarriers in novel therapeutics will be a key driver of its growth going forward.

¹ Reports and Data – Microcarrier Market Analysis 2020

Product Overview

UniTantrix^®  Microcarriers are manufactured using Tantti's patented technology, which creates a unique pore structure with very high pore connectivity and surface area.  The highly connective and uniform pores allow cells to adhere, proliferate, migrate and differentiate within the Microcarriers while simultaneously enabling the exchange of nutrients, oxygen and metabolic waste. It is manufactured with denatured collagen or other animal component-free materials without the use of chemical crosslinkers, which provides a number of advantages including flexible mechanical properties and physical stability, both of which reduce the amount of shear stress experienced by the cultured cells.  In addition, the collagen is readily dissolved with enzymes, facilitating a cell recovery rate of nearly 100%.

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